A NEW APPROACH TO PROPHYLAXIS AND THERAPY OF ENTEROHEMORRHAGIC E. COLI AND VIRAL INTESTINAL INFECTIONS

Wolfgang Luepcke, Dimitar Yakimov, Julia Ferencz, Iliyana Nacheva, Axel Wehrend, Plamen Georgiev, Teodora Sarakostova, Eva Krieps

Abstract


Enterohemorrhagic Еscherichia соli bacteria (EHEC) as well as Rota and Coronaviruses are very dangerous pathogens of severe intestinal infections in humans and animals, which require a very special approach. EHEC contraindicates the use of antibiotics, as they destroy the bacteria and release their endotoxins as a result which can lead to permanent kidney damage and even death in patients. Antibiotics are ineffective with viral pathogens, possibly only preventing secondary bacterial infections.

Based on Luepcke's many years of laboratory and practical tests, we therefore recommend the targeted use of specific colostral antibodies for the above-mentioned intestinal infections. These are obtained by means of combined intramammary and intracisternal application of attenuated pathogen isolates or vaccine strains in dry cows and goats. In this way, the first colostrum with high antibody titres is obtained, which also contains large amounts of trypsin inhibitor and thus protects the antibodies against proteolytic splitting. The first colostrum is therefore particularly valuable, because it ensures the integrity and functionality of the antibodies. This is both a basic prerequisite for their passage from the intestinal lumen into the blood (passive humoral immunity) and also ensures the effectiveness of the non-absorbed antibodies in the intestinal lumen and on the intestinal mucosa (passive local immunity). In order to accelerate the elimination of the antigen-antibody complexes that arise in the intestine in this approach, Yakimov recommends the use of a sorbent that cannot be absorbed via the intestine. Cryopreservation enables simple storage and, if necessary, easy shipping of the first colostrum produced targeted against the respective infectious agents which is to be regarded as a food supplement with simultaneous effect as an immunopreparation.

Keywords


colostrum, trypsininhibitor, maternal antibodies, immunity, Escheriсhia coli, Rotavirus, Coronavirus

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