Dimitar Yakimov, Vessela Baltova, Wolfgang Lupke, Valentin Stoyanov, Bogdana Mateva


There are evidences that flavonoids bind to and affect neutrophiles, eosinophils and macrophages. In SARS-CoV-2, the cellular immune response, especially in the first two to three weeks after infection, is expressed by the accumulation at the infection site of at most white blood cell eosinophils, neutrophiles, and monocytes/macrophages.

There have been numerous in vitro and in vivo studies on the antiviral activity of silver and copper nanoparticles, including in coronavirus infection. The our theoretical idea is that the silver nanoparticles or silver cations are transported by chelation from flavonoids to those white blood cells of the Cell-mediated immunity which are directly involved in the infection.

It was obtained and studied on Covid-19 infection a therapeutic mixture made by a controlled combining of wild basil (Clinopodium vulgare L.) tincture (66%, v/v) and other extracts of herbs rich in flavonoid and chlorogenic acid derivatives with a colloidal solution of silver nanoparticles and cations. It was found that the passing of the symptoms typical for the infection is for 3 to 10 days after the start of the treatment course. The highest percentage of patients with passed symptoms was reported from day 4 to day 6 (incl.) after initiation of dosing if therapy was initiated from day 1 to day 4 of the first symptoms. Based on this study, a Utility model "Composition for the treatment of coronaviruses" was registered with the Patent Office of the Republic of Bulgaria.


flavonoid chelate complexes, silver nanoparticles, silver cations, SARS-CoV-2, cell-mediated immunity

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